Development/Plasticity/Repair Quiescence and Activation of Stem and Precursor Cell Populations in the Subependymal Zone of the Mammalian Brain Are Associated with Distinct Cellular and Extracellular Matrix Signals

Ilias Kazanis,1* Justin D. Lathia,1,2* Tegy J. Vadakkan,3 Eric Raborn,4,5,6 Ruiqian Wan,2 Mohamed R. Mughal,2 D. Mark Eckley,7 Takako Sasaki,8 Bruce Patton,9 Mark P. Mattson,2 Karen K. Hirschi,4,5,6 Mary E. Dickinson,3 and Charles ffrench-Constant1,10 1Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom, 2Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, Departments of 3Molecular Physiology and Biophysics, 4Pediatrics, and 5Molecular and Cellular Biology and 6Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, 7Laboratory of Genetics, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, 8Department of Biochemistry and Molecular Biology and 9Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon 97239, and 10Medical Research Council Centre for Regenerative Medicine, Queen’s Medical Research Institute, Little France Crescent, Edinburgh EH16 4TJ, United Kingdom